The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder

Zongling He; Fengmei Lu; Huafu Chen

doi:doi:10.11648/j.sd.20190701.17

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The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder

Zongling He, Fengmei Lu, Huafu Chen

Published in Science Discovery (Volume 7, Issue 1)

Received: 22 February 2019 Published: 28 April 2019

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Abstract

Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.

Published in	Science Discovery (Volume 7, Issue 1)
DOI	10.11648/j.sd.20190701.17
Page(s)	26-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Major Depressive Disorder, Emotion Regulation System, Resting State, fMRI, Anhedonia

References

[1]	H. Frankish, N. Boyce, R. Horton. Mental health for all: a global goal. [J]. Lancet Glob Health, 2018 392(10157): 1493-4.
[2]	B. D. Dunn. Opportunities and Challenges for the Emerging Field of Positive Emotion Regulation: A Commentary on the Special Edition on Positive Emotions and Cognitions in Clinical Psychology [J]. Cognitive therapy and research, 2017, 41(3): 469-78.
[3]	L. Wang, D. F. Hermens, I. B. Hickie, et al. A systematic review of resting-state functional-MRI studies in major depression [J]. J Affect Disord, 2012, 142(1-3): 6-12.
[4]	I. Messina, M. Sambin, P. Beschoner, et al. Changing views of emotion regulation and neurobiological models of the mechanism of action of psychotherapy [J]. Cogn Affect Behav Neurosci, 2016, 16(4): 571-87.
[5]	E. S. Winer, J. Bryant, G. Bartoszek, et al. Mapping the relationship between anxiety, anhedonia, and depression [J]. Journal of affective disorders, 2017, 221: 289-96.
[6]	W. H. Liu, J. P. Roiser, L. Z. Wang, et al. Anhedonia is associated with blunted reward sensitivity in first-degree relatives of patients with major depression [J]. Journal of affective disorders, 2016, 190: 640-8.
[7]	J. Ventura, R. P. Liberman, M. F. Green, et al. Training and quality assurance with the Structured Clinical Interview for DSM-IV (SCID-I/P) [J]. Psychiatry Res, 1998, 79(2): 163-73.
[8]	A. Zalesky, A. Fornito, G. F. Egan, et al. The relationship between regional and inter-regional functional connectivity deficits in schizophrenia [J]. Hum Brain Mapp, 2012, 33(11): 2535-49.
[9]	A. Zalesky, A. Fornito, E. T. Bullmore. Network-based statistic: identifying differences in brain networks [J]. NeuroImage, 2010, 53(4): 1197-207.
[10]	J. Li, X. Duan, Q. Cui, et al. More than just statics: temporal dynamics of intrinsic brain activity predicts the suicidal ideation in depressed patients [J]. Psychol Med, 2018, 1-9.
[11]	J. P. Roiser, B. J. Sahakian. Hot and cold cognition in depression [J]. CNS spectrums, 2013, 18(3): 139-49.
[12]	Kevin N. Ochsner, Jennifer A. Silvers, a. J. T. Buhle. Functional imaging studies of emotion regulation: A synthetic review and evolving model of the cognitive control of emotion [J]. Ann N Y Acad Sci, 2012, 1251: E1-24.
[13]	J. Graham, G. Salimi-Khorshidi, C. Hagan, et al. Meta-analytic evidence for neuroimaging models of depression: state or trait? [J]. J Affect Disord, 2013, 151(2): 423-31.
[14]	Hedy Kobera, Lisa Feldman Barrettb, Josh Josepha, et al. Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies [J]. Neuroimage, 2008, 42(2): 998–1031.
[15]	V. Gabbay, B. A. Ely, Q. Li, et al. Striatum-based circuitry of adolescent depression and anhedonia [J]. J Am Acad Child Adolesc Psychiatry, 2013, 52(6): 628-41.
[16]	N. Watanabe, M. Sakagami, M. Haruno. Reward prediction error signal enhanced by striatum-amygdala interaction explains the acceleration of probabilistic reward learning by emotion [J]. J Neurosci, 2013, 33(10): 4487-93.
[17]	E. G. Davis, L. C. Foland-Ross, I. H. Gotlib. Neural correlates of top-down regulation and generation of negative affect in major depressive disorder [J]. Psychiatry research Neuroimaging, 2018, 276: 1-8.
[18]	G. E. Tafet, C. B. Nemeroff. The Links Between Stress and Depression: Psychoneuroendocrinological, Genetic, and Environmental Interactions [J]. J Neuropsychiatry Clin Neurosci, 2016, 28(2): 77-88.
[19]	D. A. Pizzagalli. Depression, stress, and anhedonia: toward a synthesis and integrated model [J]. Annual review of clinical psychology, 2014, 10: 393-423.
[20]	M. T. Treadway, D. H. Zald. Reconsidering anhedonia in depression: lessons from translational neuroscience [J]. Neuroscience and biobehavioral reviews, 2011, 35(3): 537-55.
[21]	N. Ichikawa, G. J. Siegle, N. P. Jones, et al. Feeling bad about screwing up: emotion regulation and action monitoring in the anterior cingulate cortex [J]. Cogn Affect Behav Neurosci, 2011, 11(3): 354-71.

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APA Style

Zongling He, Fengmei Lu, Huafu Chen. (2019). The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Science Discovery, 7(1), 26-31. https://doi.org/10.11648/j.sd.20190701.17

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ACS Style

Zongling He; Fengmei Lu; Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci. Discov. 2019, 7(1), 26-31. doi: 10.11648/j.sd.20190701.17

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AMA Style

Zongling He, Fengmei Lu, Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci Discov. 2019;7(1):26-31. doi: 10.11648/j.sd.20190701.17

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@article{10.11648/j.sd.20190701.17,
  author = {Zongling He and Fengmei Lu and Huafu Chen},
  title = {The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder},
  journal = {Science Discovery},
  volume = {7},
  number = {1},
  pages = {26-31},
  doi = {10.11648/j.sd.20190701.17},
  url = {https://doi.org/10.11648/j.sd.20190701.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190701.17},
  abstract = {Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.},
 year = {2019}
}

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TY  - JOUR
T1  - The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder
AU  - Zongling He
AU  - Fengmei Lu
AU  - Huafu Chen
Y1  - 2019/04/28
PY  - 2019
N1  - https://doi.org/10.11648/j.sd.20190701.17
DO  - 10.11648/j.sd.20190701.17
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 26
EP  - 31
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20190701.17
AB  - Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.
VL  - 7
IS  - 1
ER  -

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Author Information

Zongling He

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
Fengmei Lu

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
Huafu Chen

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China

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APA Style

Zongling He, Fengmei Lu, Huafu Chen. (2019). The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Science Discovery, 7(1), 26-31. https://doi.org/10.11648/j.sd.20190701.17

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ACS Style

Zongling He; Fengmei Lu; Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci. Discov. 2019, 7(1), 26-31. doi: 10.11648/j.sd.20190701.17

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AMA Style

Zongling He, Fengmei Lu, Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci Discov. 2019;7(1):26-31. doi: 10.11648/j.sd.20190701.17

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@article{10.11648/j.sd.20190701.17,
  author = {Zongling He and Fengmei Lu and Huafu Chen},
  title = {The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder},
  journal = {Science Discovery},
  volume = {7},
  number = {1},
  pages = {26-31},
  doi = {10.11648/j.sd.20190701.17},
  url = {https://doi.org/10.11648/j.sd.20190701.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190701.17},
  abstract = {Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder
AU  - Zongling He
AU  - Fengmei Lu
AU  - Huafu Chen
Y1  - 2019/04/28
PY  - 2019
N1  - https://doi.org/10.11648/j.sd.20190701.17
DO  - 10.11648/j.sd.20190701.17
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 26
EP  - 31
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20190701.17
AB  - Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.
VL  - 7
IS  - 1
ER  -

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